Physician · Engineer · Entrepreneur
Riley Silber, DO
I'm an internal medicine resident physician at the University of Cincinnati and co-founder of MedMatrix, an AI-driven study platform used by thousands of healthcare students nationwide.
About
Engineer by training, physician by calling.
I'm Riley Silber, DO, an internal medicine resident physician at the University of Cincinnati and an entrepreneur with a background in chemical and biological engineering. Originally from Oak Park, Illinois, I thrive on challenges and am motivated by a passion for innovative healthcare solutions.
My experience as a collegiate swimmer fostered discipline and strong teamwork skills, while my entrepreneurial ventures with MedMatrix and BAND-O2 have further developed my adaptability, leadership, and problem-solving abilities.
Education
Doctor of Osteopathic Medicine (DO)
Midwestern University – Chicago College of Osteopathic Medicine
2021 – 2026
BS, Chemical & Biological Engineering
Colorado School of Mines
2015 – 2019
Experience
Building at the intersection of engineering and medicine.
2026 – Present
Cincinnati, OH
Resident Physician, Internal Medicine
University of Cincinnati
- Internal Medicine
- Patient Care
2023 – Present
Chicago, IL
Co-Founder
MedMatrix
- Co-founded MedMatrix, an AI-driven study platform delivering dynamic, high-yield practice materials for healthcare students preparing for board exams.
- Scaled to thousands of users nationwide by forging strategic institutional partnerships and leading targeted marketing campaigns.
- Represented MedMatrix at AACOM Educating Leaders and AOA Convocation.
- Oversaw product development, marketing, sales, customer success, social media, and daily operations — taking a one-year leave from medical school to accelerate growth.
- Leadership
- Artificial Intelligence
- Business Development
- Marketing & Sales
- Medical Education
2022 – 2023
Chicago, IL
Co-Creator
BAND-O2 Pulse Oximeter Fitness Device
- Designed, engineered, and prototyped a wearable pulse oximeter for blood-flow restriction (BFR) exercise and therapeutic recovery.
- Conducted iterative performance testing to validate sensor accuracy and user comfort. Development is currently paused.
- Hardware Development
- Medical Device Design
- Prototyping
2019 – 2021
Des Plaines, IL
Associate Engineer
GTI Energy
- Led commissioning and testing of DOE-funded renewable energy projects, performing material and energy balances and interpreting experimental data.
- Designed and sized pilot-scale equipment with detailed process flow diagrams (PFDs) and piping & instrumentation diagrams (P&IDs).
- Developed standard operating procedures, authored job safety analyses, and served on the corporate safety committee.
- Engineering Project Development
- Unit Operations
- Project Management
- Technical Design
Research & honors
Studying how technology can improve medical education and care.
- PublishedApr 2026
Revisiting Robustness: Evaluating CLAHE and Test-Time Augmentation for Catheter Segmentation in X-Ray Fluoroscopy
Journal of Vascular and Interventional Radiology (SIR 2026 Annual Scientific Meeting, Abstract No. 288)
Tests whether contrast-limited adaptive histogram equalization (CLAHE) and test-time augmentation make deep-learning catheter segmentation in X-ray fluoroscopy more robust. CLAHE degraded accuracy and test-time augmentation gave only modest gains, showing that off-the-shelf techniques need modality-specific validation before clinical use.
Read the paper - Under reviewSep 2025
Evaluating the Impact of Institutional Curriculum-Controlled AI Study Materials on Biochemistry Exam Performance Among Medical Students
MedMatrix × Midwestern CCOM
A collaboration between MedMatrix and Midwestern CCOM assessing how AI-powered study materials aligned with an institution's curriculum affect biochemistry exam performance, with implications for personalized medical education.
- SubmittedJun 2025
The Efficacy of AI-Generated Questions on Medical and Nursing Student Knowledge Acquisition and Efficiency: A Learning Curve Analysis
Journal of Academic Medicine
Studies how AI-generated learning materials affect knowledge acquisition and learning efficiency among medical and nursing students, measuring learning-curve differences across educational approaches.
- PublishedDec 2024
Creating Continuity of Care Within Student-Run Free Clinics
Journal of Student Run Clinics
Examines models for maintaining continuity of care in student-run free clinics, focusing on technology-enabled solutions and process improvements that enhance patient care in these settings.
Read the paper
Gold Humanism Scholar
Midwestern University · 2023
Recognized for excellence in clinical care, leadership, compassion, and dedication to service by the Gold Humanism Honor Society.
USA Swimming Coach Certification
USA Swimming · 2024
Earned certification to coach athletes at USA Swimming–sanctioned events, covering instruction, safety, athlete development, and competition rules.
Service
Showing up for the community.
Clinical2021 – 2022
Medical Student Volunteer
IAMACF Free Health Clinic
Chicago area
Provided care to underserved communities under the supervision of attending physicians — patient intake, vital signs, medical history documentation, and assisting with basic clinical procedures.
Coaching2024 – 2025
Head Swim Coach
Team Millenium Y2K
Oak Park, IL
USA Swimming–certified head coach for the 9–10 age group. Built training plans, evaluated technique, organized meets, and kept practice positive and safe.
Community2015 – 2019
Project Manager
Be A Tool Community Service
Golden, CO
Managed community projects improving local homes and infrastructure — coordinating volunteer teams, securing resources and permits, and delivering renovations, roof repairs, and yard work on schedule.
Beyond medicine
What I do off the clock.
Exercising
Running, lifting, swimming, or climbing — it clears my head and justifies my diet.
Cooking
Experimenting with new recipes and techniques, especially dishes that combine nutrition and flavor (and some that don't).
Dungeons & Dragons
Dungeon master, world builder, and dice collector. I love creating collaborative stories and strategic adventures.
Reading
Everything from science fiction to science fact. Favorite book: The Secret Life of Lobsters.
